Lyos

TEAM III - Lysophospholipids and Bone Pathophysiology

UFR de Médecine Lyon-Est - 6ème étage rue Guillaume Paradin, 69372 Lyon cedex08 – France | Phone : +33 (0)4 78 77 86 72

LYOS – INSERM U1033,
Team «Lysophospholipids and Bone Pathophysiology»,

Université de Lyon, France.

Top 10 publications over the past 6 years

  1. Alioli CA, Demesmay L, Laurencin-Dalacieux S, Beton N, Farlay D, Follet H, Saber A, Duboeuf F, Chun J, Rivera R, Bouvard D, Machuca-Gayet I, Salles JP, Gennero I, Peyruchaud O. Expression of the type 1 lysophosphatidic acid receptor in osteoblastic cell lineage controls both bone mineralization and osteocyte specification. Biochim Biophys Acta Mol Cell Biol Lipids. 2020 Apr 21;1865(8):158715. doi: 10.1016/j.bbalip.2020.158715. PubMed PMID: 32330664.
  2. Flammier S, Peyruchaud O, Bourguillault F, Duboeuf F, Davignon JL, Norman DD, Isaac S, Marotte H, Tigyi G, Machuca-Gayet I, Coury F. Osteoclast-Derived Autotaxin, a Distinguishing Factor for Inflammatory Bone Loss. Arthritis Rheumatol. 2019 Nov;71(11):1801-1811. doi:10.1002/art.41005. Epub 2019 Sep 30. PubMed PMID: 31162832.
  3. Leblanc R, Sahay D, Houssin A, Irma Machuca-Gayet I, Peyruchaud O. (2018) Autotaxin-β interaction with the cell surface via syndecan-4 impacts on cancer cell proliferation and metastasis. Oncotarget. 9 (69): 33170-33185.
  4. Claramunt-Taberner D, Flammier S, Gaillard S, Cochat P, Peyruchaud O, Machuca-Gayet I, Bacchetta J. (2018) Bone disease in nephropathic cystinosis is related to cystinosin-induced osteoclastic dysfunction. Nephrol Dial Transplant. 33: 1525-1532.
  5. Ouarné M, Bouvard C, Boneva G, Mallet C, Ribeiro J, Desroches-Castan A, Soleilhac E, Tillet E, Peyruchaud O, Bailly S. (2018) BMP9, but not BMP10, acts as a quiescence factor on tumor growth, vessel normalization and metastasis in a mouse model of breast cancer. Journal of Experimental & Clinical Cancer Research. 37 (1):209-221.
  6. Courbon G, Flammier S, Laroche N, Vico L, Marotte H, Coury F. (2017) Tumor necrosis factor alpha overexpression induces mainly osteoclastogenesis at the vertebral site. Calcified tissue International. 100(6):575-584.
  7. Schwarzer M, Makki K, Storelli G, Machuca-Gayet I, Srutkova D, Hermanova P, Martino ME, Balmand S, Hudcovic T, Heddi A, Rieusset J, Kozakova H, Vidal H, Leulier F. Lactobacillus plantarum strain maintains growth of infant mice during chronic undernutrition. Science 2016; 351(6275):854-7.
  8. Sahay D, Leblanc R, Grunewald TG, Ambatipudi S, Ribeiro J, Clézardin P, Peyruchaud O. The LPA1/ZEB1/miR-21-activation pathway regulates metastasis in basal breast cancer. Oncotarget. 2015; 6(24):20604-20.
  9. Leblanc R, Lee SC, David M, Bordet JC, Norman DD, Patil R, Miller D, Sahay D, Ribeiro J, Clézardin P, Tigyi GJ, Peyruchaud O. Interaction of platelet-derived autotaxin with tumor integrin αVβ3 controls metastasis of breast cancer cells to bone. Blood. 2014; 124(20):3141-50.
  10. David M*, Machuca-Gayet I*, Kikuta J,Ottewell P,Mima F, Leblanc R, Bonnelye E, Ribeiro J, Holen I, Lopez Vales R, Jurdic P, Chun J, Clézardin P, Ishii M and Peyruchaud O. Lysophosphatidic acid receptor type 1 (LPA1) plays a functional role in osteoclast differentiation and bone resorption activity. (* equal contributors) J. Biol. Chem. 2014. 289(10):6551-64.