LYOS : INSERM UMR 1033, Université de Lyon, France.

TEAM 1

Roland CHAPURLAT Bone, joint and muscle chronic diseases

TEAM 2

Olivier PEYRUCHAUD Bone and Joint Pathophysiology: Bioactive lipids and mineral metabolism.

Pathophysiology, Diagnosis & Treatments of Musculoskeletal Disorders

Roland CHAPURLAT
Director

Musculoskeletal disorders, including bone diseases, osteoarthritis, inflammatory diseases, bone metastasis and sarcopenia are responsible for a major disease burden worldwide. There remains an important gap in terms of pathophysiology understanding, diagnosis and therapy that we address. We conduct research in this area from bench to bedsite, thanks to a wide platform including cell biology, animal models, biomechanics studies, epidemiology and clinical research.

Our scientific strategy hinges on 2 teams.

Team 1’s major objectives are to improve the prediction of fracture risk in men and women with osteoporosis. The relations between bone and certain chronic diseases will be also studied. It has become obvious (albeit little understood) that bone quality is influenced by chronic diseases and, conversely, that bone remodeling participates in the genesis of chronic diseases.

Team 2’s main objectives are to study the pathophysiological role of bioactive lipids (lysophosphatidic acid, leukotrienes), calcium phosphate metabolism in rare diseases, benign (osteoporosis, rheumatoid arthritis) and cancerous (bone metastasis) bone pathologies.